A frequently asked question is whether Rollup N for Exchange X is supported with Enterprise Vault. Most commonly the question arises from Outlook Web Access support. You can substitute N for any number and X for either 2007 or 2010.
Take for example recently, a post asked if Exchange 2010 SP 1 Rollup 2 was supported or not.
The answer to this is that rollups are not specifically tested by the certification or QA teams, it would be a nearly never ending job to try to tackle them all. That’s not to say that they don’t work – 99.9% of the time there are no problems. If a problem *is* encountered you can definitely call Support and work with them to investigate the problem, and if a fix is needed then that is also possible.
The only rollup that I know of to date which broke the OWA extensions for Enterprise Vault is Update Rollup 2 for Exchange 2007 SP 2 : http://support.microsoft.com/?id=972076. This resulted in an Enterprise Vault 8 SP 3 hotfix, and inclusion in EV 8 SP 4, and EV 9.